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近年来陆续发现了一些中枢神经轴突生长的抑制因子,如Nogo-A、MAG、OMgp等。目前已发现,它们可通过一个共同的NgR-P75-LINGO-1受体复合物,将抑制信号导入神经元胞内,进一步传递给Rho-A,引起一系列的反应,最终导致生长锥的溃变。除了Rho-A途径外,还存在其它信号途径,如Enabled途径和LIMK途径,以及一些间接的、调节性的信号途径,它们共同作用,传递髓鞘的抑制信号,抑制神经突的生长和轴突的再生。探明抑制信号的传导过程对于克服中枢神经的再生障碍有着重要意义。
In recent years, one after another found some central nervous axon growth inhibitory factor, such as Nogo-A, MAG, OMgp and so on. It has now been found that they can pass inhibitory signals into intracellular neurons via a common NgR-P75-LINGO-1 receptor complex and further transfer to Rho-A, causing a series of reactions that eventually lead to growth cone collapse change. In addition to the Rho-A pathway, there are other signaling pathways, such as the Enabled pathway and the LIMK pathway, as well as indirect and regulatory signaling pathways that work together to deliver myelin suppression signals and inhibit neurite outgrowth and axons The regeneration. It is of great significance to prove that the process of inhibiting signal transduction can overcome the regeneration of central nervous system.