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为优选适宜玄参现代干燥工艺参数,该研究根据玄参传统干燥加工过程,结合现代干燥设备特点,将其模拟为以下3个阶段:控温干燥-缓苏-控温干燥。选择一段温度、风速及目标含水率,缓苏温度及时间,二段温度及风速7个因素,应用L_(18)(3~7)正交设计进行干燥试验,加工得18批干燥样品;采用UPLC-TQ-MS测定各干燥样品及19批道地产地样品中梓醇、哈巴苷、毛蕊花糖苷、阿魏酸、安格洛苷-C、桃叶珊瑚苷、哈巴俄苷、肉桂酸、熊果酸共9种指标性成分的含量。根据成分含量的主成分分析(PCA)与能耗结果进行分析评价。结果显示,第一阶段干燥温度60℃、干燥风速50 Hz、干燥目标水分50%;第二阶段缓苏时间24 h、温度20℃;第三阶段干燥温度60℃、干燥风速30 Hz为最佳工艺。应用优选的玄参现代干燥工艺加工的药材,不仅外观与有效成分含量与收集的道地产地药材非常相似,亦符合2015年版《中国药典》的要求,且可大幅缩短干燥加工时间,提高药材产地初加工的效率,可实现药材产地初加工的规范化。
In order to optimize the modern drying process parameters of Scrophulariaceae, according to the traditional drying process of Scrophulariaceae, combined with the characteristics of modern drying equipment, the study was simulated as the following three stages: temperature-controlled drying-slowing down-temperature-controlled drying. Select a temperature, wind speed and target moisture content, temperature and time of subsidence, temperature and wind speed of the second stage seven factors, the application of L_ (18) (3 ~ 7) orthogonal design of drying test, processing 18 batches of dry samples; UPLC-TQ-MS was used to determine the contents of catalpol, hababoside, verbascoside, ferulic acid, angoside-C, aucubin, harpagoside, cinnamic acid, A total of 9 kinds of acid content of the ingredients. According to the content of the principal component analysis (PCA) and energy consumption results were analyzed and evaluated. The results showed that the drying temperature in the first stage was 60 ℃, the drying speed was 50 Hz, and the drying target moisture was 50%. The second stage was 24 h and the temperature was 20 ℃. The third stage was 60 ℃ and the drying speed was 30 Hz Process. The best choice of the modern drying process of figwort Dried herbs, not only the appearance and content of active ingredients collected from the Roadside medicines are very similar, also in line with the 2015 edition of the “Chinese Pharmacopoeia” requirements, and can significantly reduce the drying time and improve the origin of medicinal herbs The efficiency of initial processing, can achieve the standardization of raw processing of raw materials.