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电刺激三叉神经节或静脉注射辣椒素造成大鼠硬脑膜内血浆蛋白渗出，取下双侧硬脑膜称重并测量其放射性。分别于刺激前４０ｍｉｎ腹腔注射ＨＬ－３２９１０、２０、４０ｍｇ／ｋｇ或相同容量溶剂，观察它们的作用。结果显示电刺激增加了刺激侧硬脑膜内血浆蛋白渗出〔（２１．５０±１．４５）～（３７．８５±３．１９）ｃｐｍ／ｍｇ，Ｐ＜０．０１〕，刺激侧与非刺激侧的比值为１．７６±０．１０。ＨＬ－３２９１０，２０，４０ｍｇ／ｋｇ分别减少其比值到１．５３±０．１４（Ｐ＜０．０５），１．４３±０．０３（Ｐ＜０．０１），１．２０±０．１５（Ｐ＜０．０１）。ＨＬ－３２９明显减少了电刺激和辣椒素造成的大鼠硬脑膜内血浆蛋白渗出。证明ＨＬ－３２９是一潜在的抗偏头痛药物
Electrical stimulation of the trigeminal ganglion or intravenous injection of capsaicin causes plasma protein exudation in the dura mater of rats and bilateral dura mater is weighed and the radioactivity is measured. The mice were injected intraperitoneally with HL-32910, 20, 40 mg / kg or the same volume of solvent 40 minutes before stimulation to observe their effects. The results showed that electrical stimulation increased the exudation of plasma protein in the stimulation dura [(21.50 ± 1.45) ~ (37.85 ± 3.19) cpm / mg, P <0.01] The stimulation side ratio was 1.76 ± 0.10. HL-32910, 20 and 40 mg / kg, respectively, decreased to 1.53 ± 0.14 (P <0.05), 1.43 ± 0.03 (P <0.01), 1.20 ± 0. 15 (P <0.01). HL-329 significantly reduced electrical stimulation and capsaicin induced plasma protein exudation in the rat’s dura. HL-329 proved to be a potential anti-migraine drug