论文部分内容阅读
药学监护(Pharmaceutical Care)作为医院药学工作的一种崭新模式,在改善药物治疗以及提高病人生命质量方面的作用正越来越多地被人们所认识。儿科病人作为一个特殊的病人群体,药物在这一病人群体中的药动学、药效学、疗效和不良反应与成年人存在明显差异。二十世纪60年代,根据成年人对氯霉素的反应资料外推在新生儿中使用该药物,导致患儿用药后出现严重的“灰婴综合征”。这一事件告诉我们需要重视在儿科与成年病人之间甚至在儿科病人中由于年龄、器官功能和疾病状态不同所导致药物反应的显著差异。在儿科病人中开展药学监护工作具有十分重要的意义,应该受到足够重视。
As a brand new model of hospital pharmacy, Pharmaceutical Care plays an increasingly important role in improving drug treatment and improving patient quality of life. Pediatric patients as a special patient group, the drug in this patient population pharmacokinetics, pharmacodynamics, efficacy and adverse reactions were significantly different from adults. In the 1960s, the use of this drug in newborns was extrapolated from adults’ data on the response to chloramphenicol, leading to severe “gray baby syndrome” in children. This incident tells us that we need to pay attention to the significant differences in drug response between pediatric and adult patients and even in pediatric patients due to differences in age, organ function and disease status. Pharmacological care in pediatric patients is of great importance and deserves sufficient attention.