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3-羟基哌啶经N-叔丁氧羰基保护、次氯酸钠-TEMPO氧化、酮还原酶K198不对称催化还原得到依鲁替尼手性中间体(S)-1-叔丁氧羰基-3-羟基哌啶,总收率70%。
3-Hydroxypiperidine was protected by N-tert-butoxycarbonyl, sodium hypochlorite-TEMPO oxidation and asymmetric catalytic reduction with ketoreductase K198 to give ibrutinib chiral intermediate (S) -1-tert-butoxycarbonyl-3-hydroxy Piperidine, the total yield of 70%.