论文部分内容阅读
目的:探讨老年支气管哮喘病症应用孟鲁司特联合布地奈德治疗的临床效果,总结相关临床治疗经验。方法:选取2005年3月-2013年9月笔者所在医院收治的老年支气管哮喘患者80例,按照随机数字表法分成对照组和观察组,每组40例。对照组患者采用抗生素、多索茶碱、布地耐德、硫酸特布他林进行常规治疗,而观察组患者在对照组治疗的基础上加用孟鲁司特联合治疗,对两组患者的临床疗效进行观察比较。结果:药物治疗10 d后进行肺功能指标测量,两组肺活量比值(FEV1/FVC%)、呼气峰值流速(PEF)均明显提升,与治疗前比较差异均有统计学意义(P<0.05)。且观察组肺活量比值(FEV1/FVC%)、呼气峰值流速(PEF)提升更显著,与对照组比较差异有统计学意义(P<0.05)。两组患者出院后1年内进行跟踪随访,对照组有11例(27.5%)病情反复再次住院治疗,而观察组只3例(7.5%)患者复发再次住院,观察组再住院率明显低于对照组,两组比较差异有统计学意义(P<0.05)。结论:老年支气管哮喘应用孟鲁司特联合布地奈德治疗疗效显著,能够有效改善患者的肺功能指标,大大提高患者临床治疗效果,值得推广应用。
Objective: To investigate the clinical effects of montelukast combined with budesonide in elderly patients with bronchial asthma and to summarize the experience of clinical treatment. Methods: Eighty elderly patients with bronchial asthma admitted to our hospital from March 2005 to September 2013 were selected and randomly divided into control group and observation group according to random number table. Each group included 40 cases. The patients in the control group were treated with antibiotics, doxofylline, budesonide and terbutaline sulphate. The patients in the observation group were treated with montelukast in combination with the control group, The efficacy of observation and comparison. Results: The indexes of pulmonary function were measured after treatment for 10 days. The volume of vital capacity (FEV1 / FVC%) and peak expiratory flow (PEF) of the two groups were significantly increased after treatment, which were significantly different from those before treatment (P <0.05) . (FEV1 / FVC%) and peak expiratory flow (PEF) in the observation group increased more significantly than those in the control group (P <0.05). In the control group, 11 patients (27.5%) were hospitalized again and again and only 3 patients (7.5%) in the observation group were relapsed and hospitalized again. The rehospitalization rate in the observation group was significantly lower than that in the control group Group, the difference between the two groups was statistically significant (P <0.05). Conclusion: The treatment of elderly patients with bronchial asthma with montelukast combined with budesonide has significant curative effect, which can effectively improve the lung function indexes of patients and greatly improve the clinical curative effect of the patients, which is worth popularizing and applying.