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降压药物已普遍用于重、中度甚至轻度的高血压患者,目的是控制血压,防止其发生并发症。但直到现在为止一些大规模调查试验均未能证明抗高血压治疗能够改善冠心病的死亡率和预防冠心病的发生。这提示普遍应用降压药物并不能提高降压所取得的益处。本文主要通过降压药物对与动脉粥样硬化有关的脂蛋白代谢的影响,阐明临床应用时必须注意。
Antihypertensive drugs have been commonly used in patients with severe, moderate or mild hypertension in order to control blood pressure and prevent their complications. However, up to now, some large-scale investigations have failed to prove that antihypertensive treatment can improve the mortality rate of coronary heart disease and prevent the occurrence of coronary heart disease. This suggests that the widespread use of antihypertensive drugs does not increase the benefits of blood pressure reduction. This article mainly through the antihypertensive drugs on atherosclerosis-related lipoprotein metabolism, to clarify the clinical application must pay attention.