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以新生鼠头盖骨体外培养作为模型,观察牙周袋壁组织培养液的骨吸收活性,及肖炎痛和放线菌酮的抑制效应,发现袋壁组织培养液能明显促进新生鼠头盖骨Ca~(2+)的释放(骨吸收活性为44.2±4.1％,对照组为18.7±2.3％,p<0.01),在袋壁组织的培养过程中加入消炎痛(100ng/ml)或放线菌酮(10μg/ml)并经透析,则明显抑制其骨吸收活性(抑制57.3％和77.3％)。说明PG和IL-1等都可能在体内牙槽骨的吸收过程中有着重要意义,并为临床用药物阻断牙槽骨吸收提供了理论依据。
The newborn rat skull bone culture in vitro as a model to observe the periodontal pocket wall tissue culture fluid bone resorption activity, and Xiao Yan pain and cycloheximide inhibitory effect and found that bag wall tissue culture fluid can significantly promote newborn rat cranium Ca ~ ( (Bone resorption activity was 44.2 ± 4.1% in the control group, 18.7 ± 2.3% in the control group, p <0.01). Indomethacin (100ng / ml) or cycloheximide 10 μg / ml) and dialyzed significantly inhibited its bone resorption activity (57.3% and 77.3% inhibition). These results indicate that PG and IL-1 may play an important role in the process of alveolar bone absorption in vivo and provide a theoretical basis for clinical use of drugs to block alveolar bone resorption.