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目的 探讨CD44v6表达与胃癌生物学行为及转移的关系。方法 应用免疫组织化学方法检测CD44v6在 2 0 5例胃癌组织中的表达。结果 胃癌CD44v6表达阳性率为 47 3% (97/ 2 0 5 )。分化型胃癌的v6阳性率为 6 7 4% (5 8/ 86 ) ,未分化型胃癌的阳性率为 32 8% (39/ 119) ,两者差异有显著性 (χ2 =2 2 70 ,P <0 0 0 1)。v6的表达在静脉侵犯组为 5 3 6 % (6 7/ 12 5 ) ,较无静脉侵犯组 (37 5 % ,30 / 80 )为高 (χ2 =4 45 ,P <0 0 5 )。肝转移组的v6阳性率为 70 2 % (33/ 47) ,明显高于无肝转移组(4 0 5 % ,6 4/ 15 8) (χ2 =11 6 6 ,P <0 0 0 1)。结论 CD44v6对胃癌的血源性转移起重要作用
Objective To investigate the relationship between CD44v6 expression and biological behavior and metastasis of gastric cancer. Methods Immunohistochemistry was used to detect the expression of CD44v6 in 205 cases of gastric cancer. Results The positive rate of CD44v6 expression in gastric cancer was 47 3% (97/250). The positive rate of v6 in differentiated gastric cancer was 67.4% (58/86), while the positive rate of undifferentiated gastric cancer was 32.8% (39/119), the difference was significant (χ2 = 2 2 70, P <0 0 0 1). The expression of v6 was 53.6% (67/25) in the venous invasion group and 35.5% (30/80) in the non-venous invasion group (χ2 = 455, P <0 05). The positive rate of v6 in the liver metastasis group was 70 2% (33/47), which was significantly higher than that in the non-hepatic metastasis group (40.5%, 64/158) (χ2 = 11 6 6, P 0 01) . Conclusion CD44v6 plays an important role in the hematogenous metastasis of gastric cancer