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本文报告3例因不同原因接受雄激素类药物长期治疗而诱发肝癌的男性病例,年龄28～40岁。例1于1968年12月开始服用福康隆(Oxymetholone),每日剂量100～150毫克。至1973年6月发现肝大,肝扫描显示多处稀疏区。1974年3月肝扫描缺损区扩大至整个右叶,活检证实为肝肿瘤。遂停药。在随后9个月内腹部症状消失,肝明显缩小,肝扫描显示缺损区逐渐缩小。例2曾服用甲睾酮6年(每日50毫克),1970年12月入院发现上腹部有肿块,肝扫描显示左叶明显稀疏,右叶有一小缺损区,剖腹发现左叶有一18×14×12厘米的肿瘤,右叶有3个瘤性小结节。将肿瘤切除。术后继续服用甲睾酮每日50毫克,随访至1974年9月肝扫描缺损区轻度增大。停用甲睾酮,1974年12月肝扫描右叶缺损区缩小。例3曾用甲睾酮
This article reports 3 cases of male patients with liver cancer induced by long-term treatment of androgen drugs for different reasons, aged 28 to 40 years. Example 1 began taking Oxymetholone in December 1968 at a daily dose of 100-150 mg. The liver was found to be large in June 1973 and the liver scan showed multiple sparse areas. In March 1974, the liver scan defect area was expanded to the entire right lobe and biopsy was confirmed as liver tumor. Stop the medicine. In the following 9 months, the abdominal symptoms disappeared, the liver was significantly reduced, and the liver scan showed a gradual reduction of the defect area. Example 2 had been treated with methyltestosterone for 6 years (50 mg per day). He was admitted to the hospital in December 1970 and had a lump in the upper abdomen. Hepatic scan showed a sparse left lobe and a small defect in the right lobe. He had a left side 18 x 14 x A 12 cm tumor has 3 nodules in the right lobe. Remove the tumor. Continue to take the testosterone 50 mg daily after surgery and follow up until September 1974. The liver scan defect area is slightly increased. Methyltestosterone was stopped, and the right lobe defect area was reduced in liver scans in December 1974. Example 3 used methyltestosterone