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新生儿缺氧缺血性脑病(HIE)是由于围产期窒息引起的脑组织缺氧、缺血性改变。在其病理过程中,脑细胞缺氧,脑血流灌注异常为其主要病理变化。近年来,内源性阿片样物质在HIE病程中的作用日益受到重视。高压氧可数倍地提高脑组织中氧分压,并增加氧弥散功能;逆转脑缺氧造成的病理改变,纳络酮则能有效逆转内源性阿片样物质所介导的各种效应,我们在常规治疗基础上,采用高压氧纳络酮联合治疗新生儿重症HIE取得了较好疗效,结果报道如下。
Neonatal hypoxic-ischemic encephalopathy (HIE) is due to hypoxia, ischemic changes of brain tissue caused by perinatal asphyxia. In its pathological process, brain cells hypoxia, cerebral perfusion abnormalities as its main pathological changes. In recent years, the role of endogenous opioids in the course of HIE has been paid more and more attention. Hyperbaric oxygen can increase the partial pressure of oxygen in brain tissue several times and increase oxygen diffusion function; reverse the pathological changes caused by cerebral hypoxia, naloxone can effectively reverse the endogenous opioid mediated various effects, We are based on conventional treatment, the use of hyperbaric oxygen naloxone combined treatment of severe neonatal HIE has achieved good results, the results reported below.