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目的：探讨了以 Ｐ５３蛋白为代表的分子切缘与常规细胞病理切缘的关系以及切除肿 瘤各边缘５．０ ｃｍ的组织是否安全可靠方法：对４９例胃肠道恶性肿瘤的瘤中心组织及肿瘤 边缘每隔 ０．５ ｃｍ取材至上、下切缘５．０ ｃｍ处，采用免疫组化 Ｓ－Ｐ法检测Ｐ５３蛋白，并与对应 位点的病理切片相比较．结果：距肿瘤切缘愈远，Ｐ５３蛋白表达率意低，Ｐ５３蛋白阳性表达与 细胞病理切缘阳性在各位点上相一致．在胃癌中，上切缘阳性范围不超过２．５ ｃｍ，下切缘不 超过 ３．０ ｃｍ；在大肠癌中，上切缘阳性不超过 １．０ ｃｍ，下切缘阳性不超过 １．５ ｃｍ．结论： 以 Ｐ５３为代表的分子切缘的概念可补充细胞切缘的概念，两者结合有助于提高病理诊断的准 确性和可信度．距胃肠道恶性肿瘤各边缘 ５．０ ｃｍ的切缘范围是安全可靠的。
OBJECTIVE: To investigate whether the relationship between the molecular cutting edge represented by P53 protein and conventional cytopathological margin and whether the removal of 5.0 cm at each edge of the tumor is safe and reliable. Methods: 49 cases of gastrointestinal malignant tumor center organization and The tumor margin was drawn at 0.5 cm intervals from the top and the bottom of the margin to 5.0 cm. P53 protein was detected by immunohistochemical S-P method and compared with the corresponding pathological sections. Results: The farther away from the tumor margin, the lower the expression of P53 protein, the positive expression of P53 protein was consistent with the positive of cytopathological positive margin at each site. In gastric cancer, the positive margin of the upper margin does not exceed 2.5 cm and the lower margin of the margin does not exceed 3.0 cm. In colorectal cancer, the positive margin does not exceed 1.0 cm and the lower margin does not exceed 1.5 cm . Conclusion: The concept of molecular cutting edge represented by P53 can supplement the concept of cell margin, and the combination of the two can help to improve the accuracy and reliability of pathological diagnosis. A margin of 5.0 cm from each edge of a gastrointestinal malignancy is safe and reliable.