细胞周期蛋白(Cyclin)是一类对细胞周期起关键调控作用的蛋白。这些蛋白中包含一些同源区域,例如细胞周期素盒以及细胞周期素盒之外的其它同源区域[1]。在哺乳动物细胞中,细胞周期蛋白与细胞周期蛋白依赖性激酶(CDK)结合形成复合物,参与不同细胞周期的调控过程。其中:CyclinD-CDK4/6复合物控制G1期进程,CyclinE-CDK2复合物调控G1/S期转换过程,CyclinA-CDK2复合物对S期起关键调控作用, Cyclin is a type of protein that plays a key regulatory role in the cell cycle. Some of these proteins contain homologous regions, such as the cyclin box and other homologous regions other than the cyclin box [1]. In mammalian cells, cyclin binds to cyclin-dependent kinases (CDKs) to form complexes that are involved in the regulation of different cell cycles. Among them, the CyclinD-CDK4 / 6 complex controls the G1 phase process, the CyclinE-CDK2 complex regulates the G1 / S phase transition process, and the CyclinA-CDK2 complex plays a key regulatory role on the S phase.