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目的探讨血浆中可溶性血栓调节蛋白(sTM)变化与老年高血压病并发缺血性脑卒中的关系,为早期干预、防治老年高血压病并发缺血性脑卒中提供理论依据。方法采用前瞻性研究方法,选取69例老年高血压病并发缺血性脑卒中的患者作为实验组,另选69例健康者作为对照组,采集受试者空腹肘静脉血,应用酶联免疫吸附法(ELISA)测定测定血浆中sTM的水平。结果治疗前实验组和对照组血浆sTM水平比较,实验组(50.21±11.56)ng/mL,对照组(13.26±2.98)ng/mL,差异有统计学意义(P<0.05);治疗前按照高血压分级进行t检验,三组之间差异均有统计学意义(P<0.05);治疗后1周、2周和3周进行比较,三组之间差异均有统计学意义(P<0.05)。结论检测sTM可作为老年高血压病并发缺血性脑卒中血管内皮损伤的观察指标,对防治老年高血压病并发缺血性脑卒中有重要的临床意义。
Objective To investigate the relationship between plasma soluble thrombomodulin (sTM) and elderly hypertensive patients with ischemic stroke, and to provide a theoretical basis for early intervention and prevention and treatment of elderly hypertensive patients with ischemic stroke. Methods A prospective study was conducted in 69 elder patients with hypertension complicated by ischemic stroke. The other 69 healthy people were selected as the control group. Fasting elbow venous blood was collected from the patients. ELISA was performed using enzyme-linked immunosorbent assay Method (ELISA) assay determines the level of sTM in plasma. Results Compared with the control group (50.21 ± 11.56) ng / mL and control group (13.26 ± 2.98) ng / mL, the levels of sTM in the experimental group and the control group before treatment were significantly different (P <0.05) (P <0.05). After 1 week, 2 weeks and 3 weeks after treatment, there was significant difference between the three groups (P <0.05) . Conclusion The detection of sTM can be used as an indicator of vascular endothelial injury in elderly patients with hypertension and ischemic stroke, and has important clinical significance in the prevention and treatment of senile hypertension and ischemic stroke.