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目的:探讨青蒿素类抗疟药的药效和联合用药的意义。方法:选取惠州市中心人民医院2015年6月至2016年4月收治的150例疟疾患者,采用临床随机分配法分为3组,分别为对照1组、对照2组、观察组,各50例。对照1组患者给予青蒿素药物治疗,对照2组患者给予奎宁药物治疗,观察组患者给予青蒿素联合奎宁药物治疗。观察对比3组患者的药物治疗效果,以及联合用药的疟疾发作率。结果:3组药物治疗效果为对照2组(80.0%)<对照1组(90.0%)<观察组(100.0%),疟疾复发率为对照2组(20.0%)>对照1组(10.0%)>观察组(2.0%),差异具有统计学意义(P<0.05)。结论:青蒿素类抗疟药的药效显著,治愈率高,且副作用少,联合用药临床效果更加明显,可降低疟疾的复发率。
Objective: To investigate the efficacy of artemisinin-based antimalarial drugs and the significance of combination therapy. Methods: A total of 150 cases of malaria patients who were treated in Huizhou Central People’s Hospital from June 2015 to April 2016 were selected and randomly divided into three groups: control group 1, control group 2, observation group 50 cases . Control group 1 patients were given artemisinin drug treatment, control group 2 patients were given quinine drug treatment, observation group patients given artemisinin combined quinine drug treatment. To compare the efficacy of the three groups of patients treated with drugs, as well as the incidence of malaria in combination. Results: The efficacy of the three groups was compared with control group 2 (80.0%) Observation group (2.0%), the difference was statistically significant (P <0.05). Conclusion: The artemisinin-based anti-malarial drug has significant efficacy, high cure rate and few side effects. The clinical effect of combination therapy is more obvious, which can reduce the relapse rate of malaria.