大颗粒淋巴细胞在与自身瘤细胞相互作用过程中,释放一种介导自身瘤细胞裂解的可溶性细胞毒因子。这种因子被称为大颗粒淋巴细胞来源的细胞毒因子(LGL-CF)。本文中把LGL-CF 与其它细胞纯化的人重组细胞毒因子,包括TNF、LT、IFNα、IFNγ、IL-1α、IL-2,作了比较。作者把淋巴细胞或纯化的LGL 与新鲜的自身瘤细胞混合培养1小时,培养上清中即含有LGL-CF。细胞因子的裂解活性和细胞介导细胞毒分别做18小时和4小时~(51)Cr 释放 Large particles of lymphocytes in their interaction with their own tumor cells, the release of a self-tumor cell lysis of soluble cytotoxic agents. This factor is known as large granular lymphocyte-derived cytotoxic factor (LGL-CF). In this work, we compared LGL-CF with other recombinant human cytotoxic cytokines, including TNF, LT, IFNα, IFNγ, IL-1α and IL-2. The authors mixed lymphocytes or purified LGL with fresh self-tumor cells for 1 hour, and culture supernatants contained LGL-CF. Cytokinolytic activity and cell-mediated cytotoxicity were done 18 hours and 4 hours ~ (51) Cr release