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目的:观察中药参术扶正抗癌汤加减联合同步放化疗治疗老年局部晚期非小细胞肺癌的疗效及药物不良反应。方法:89例患者随机分为两组,对照组在三维适形放疗同时行化疗,紫杉醇60 mg·m~(-2),ivd,1次/周,连用3周,停药1周,共2个周期;观察组在对照组放化疗基础上,加用参术扶正抗癌汤200 ml,po,bid。比较两组患者近期疗效、临床症状、生存质量及药物不良反应。结果:两组患者近期疗效、临床症状改善、生存质量等方面比较,观察组明显优于对照组(P<0.05或0.01)。观察组骨髓抑制及消化道反应发生率及程度均显著低于对照组(P<0.05或0.01)。两组患者肝、肾功能、心脏毒性及神经毒性等不良反应发生率比较,差异无统计学意义(P>0.05)。结论:参术扶正抗癌汤加减与周剂量用紫杉醇联合三维适形放疗同步治疗老年局部晚期非小细胞肺癌可以提高临床疗效及治疗依从性,改善患者生存质量,值得临床推广应用。
Objective: To observe the curative effect and adverse drug reaction of Fuzheng Kangai Decoction combined with concurrent chemoradiotherapy in elderly patients with locally advanced non-small cell lung cancer. Methods: Eighty-nine patients were randomly divided into two groups. Patients in the control group were treated with three-dimensional conformal radiotherapy concurrently with chemotherapy, paclitaxel 60 mg · m -2, iv d, once a week for 3 weeks. 2 cycles; the observation group in the control group on the basis of radiotherapy and chemotherapy, plus Senate Fuzheng anti-cancer soup 200 ml, po, bid. Short-term efficacy, clinical symptoms, quality of life and adverse drug reactions were compared between the two groups. Results: The two groups of patients with short-term efficacy, clinical symptoms, quality of life and other aspects, the observation group was significantly better than the control group (P <0.05 or 0.01). The incidence and extent of myelosuppression and gastrointestinal reaction in the observation group were significantly lower than those in the control group (P <0.05 or 0.01). There was no significant difference in the incidence of adverse reactions such as liver and kidney function, cardiotoxicity and neurotoxicity between the two groups (P> 0.05). Conclusion: The concurrent treatment of Fuzheng Kangzheng Decoction with weekly dose of paclitaxel combined with three-dimensional conformal radiotherapy for elderly locally advanced non-small cell lung cancer can improve clinical efficacy and treatment compliance and improve the quality of life of patients, worthy of clinical application.