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目的对几近100%低钾周期性麻痹患者合并外周血白细胞计数增高的原因进行研究,同时对此病的病因及合理的治疗方法一并作粗略探讨。方法对160例低钾周期性麻痹患者随机分为例数相同的4组后分别采用不同的方法治疗,连续监测各组病人血钾浓度、外周血白细胞计数、血浆皮质醇浓度,研究各项指标变化的关联性。结果是否使用抗生素并不改变白细胞计数的变化趋势;随着病人血浆皮质醇浓度下降至正常范围,血钾浓度及外周白细胞计数也缓慢而平稳地恢复至正常范围。结论感染并非外周血白细胞升高的主要原因,低血钾与高血像可能均系应激反应的结果,为小剂量缓慢补钾的合理性找到又一证据;尽快地消除应激因素可能是比补充钾盐更为重要的举措。
Objective To study the causes of the increase of peripheral white blood cell count in nearly 100% of patients with hypokalemic periodic paralysis and at the same time make a rough discussion about the etiology and reasonable treatment of this disease. Methods A total of 160 patients with hypokalemic periodic paralysis were randomly divided into 4 groups with the same number of cases and treated with different methods respectively. The serum potassium concentration, peripheral blood leukocyte count and plasma cortisol concentration were continuously monitored in each group. The relevance of change. The results of using antibiotics did not change the trend of white blood cell count; with the patient’s plasma cortisol concentration fell to the normal range, serum potassium concentration and peripheral white blood cell count also slowly and smoothly returned to normal range. Conclusions Infection is not the main reason for the increase of leukocytes in peripheral blood. Both hypokalemia and hyperkinetic may be the result of stress response, so as to find another evidence for the rationality of low-dose slow-acting potassium supplement. Eliminating stress as soon as possible may be More important than the additional potassium salt move.