本文在动物实验和生物热模型分析的基础上,用计算机数值模拟求解和参数估计的方法求得了组织间激光血卟啉治疗肿瘤的一维瞬态温度场、激光在组织间的穿透深度、以及生物组织血流率在加温过程中的变化,并对温度场进行了实验检验。探讨了肿瘤供血系统的调节功能。分析了对肿瘤进行血卟啉光动力学疗法的热效应,讨论了多根光纤插入动物组织时的复合温度场和光纤的最佳间距及治疗有效半径的问题。 Based on the animal experiments and the bio-thermal model analysis, the one-dimensional transient temperature field, the penetration depth of the laser between the tissues and the tissue of the laser-induced hematoporphyrin in the tissue were obtained by computer numerical simulation and parameter estimation. As well as the change of blood flow rate of biological tissue during the heating process, and the temperature field was tested experimentally. Exploring the regulatory function of the tumor blood supply system. The thermal effect of hematoporphyrin photodynamic therapy on tumors was analyzed. The complex temperature field and the optimum spacing of optical fibers and the effective radius of the treatment were discussed when multiple optical fibers were inserted into animal tissues.