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目的 探讨马氏钳蝎毒抗癌多肽 (APBMV)单独及其与 5 Fu联合对小鼠肝癌抑瘤作用。方法 采用小鼠腹水型肝癌H2 2 的荷瘤模型观察了APBMV的体内抑瘤作用和对 5 Fu抑瘤作用的影响。结果 APBMV在所用剂量 [(0 .0 3 0 .0 6)mg (kg·d) ,用 10d]范围内对H2 2 荷瘤小鼠无显著的抑瘤作用。 5 Fu 2 0mg (kg·d)用 10d虽有较好的抑瘤效应 ,却有明显毒性反应。将 5-Fu剂量降低 1 2、1 4与APBMV合用则有良好的抑瘤作用 (生命延长率为 10 3 .8%、2 0 .4 % ,P <0 .0 5)且无明显的毒性反应。结论 APBMV可显著增强 5 Fu对肝癌的疗效、降低其毒性。
Objective To investigate the anti-tumor effects of anti-cancer polypeptide (APBMV) from Malpighella pneumoniae alone and its combination with 5 Fu on liver cancer in mice. Methods The tumor-bearing model of mouse ascitic hepatoma H2 2 was used to observe the anti-tumor effect of APBMV in vivo and its effect on the anti-tumor effect of 5 Fu. Results APBMV had no significant inhibitory effect on H22 tumor-bearing mice in the range of [(0.30 0.6 g) mg (kg·d)] for 10 days. Although 5 Fu 2 0mg (kg·d) had better anti-tumor effect with 10d, there was obvious toxicity. Combining a dose of 5-Fu with a dose of 12 or 14 combined with APBMV had a good anti-tumor effect (life extension rate was 103.8%, 20.4%, P < 0.05) and no significant toxicity was observed. reaction. Conclusion APBMV can significantly enhance the effect of 5 Fu on liver cancer and reduce its toxicity.