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目的探讨肺原发性黏膜相关淋巴组织淋巴瘤的临床诊断与治疗方法。方法对1992年8月至2005年5月收集的12例肺原发性黏膜相关淋巴组织淋巴瘤(MALTlymphoma)患者的临床资料、治疗、随访结果进行总结。结果随访6~164个月(平均70.3个月),12例目前均存活。手术治疗6例,术后化疗4例。单纯化疗4例,2例为完全缓解,2例为部分缓解。临床观察2例,带病生存。1例术后12.7年复发,随访8个月生存良好。结论肺原发性黏膜相关淋巴组织淋巴瘤临床表现无特异性,但其胸部放射线检查较为特异,表现为边缘模糊,内有充气支气管征的肿块。该病主要依靠病理组织学及免疫组化诊断。手术治疗结合化疗或者单纯化疗,疗效均较满意,是一种预后相对良好的恶性肿瘤。
Objective To investigate the clinical diagnosis and treatment of pulmonary primary mucosa-associated lymphoid tissue lymphoma. Methods The clinical data, treatment and follow-up results of 12 patients with primary pulmonary mucosal lymphoma (MALT lymphoma) collected from August 1992 to May 2005 were summarized. The results were followed up for 6 to 164 months (mean 70.3 months), and 12 cases were alive at present. Surgical treatment in 6 cases, postoperative chemotherapy in 4 cases. There were 4 cases of chemotherapy alone, 2 cases of complete remission, and 2 cases of partial remission. Clinical observation of 2 cases, disease-free survival. One patient had recurrence at 12.7 years and survived at 8 months follow-up. Conclusion The clinical manifestations of primary pulmonary mucosa-associated lymphoid tissue lymphoma are non-specific, but the chest radiographic examination is more specific. It is characterized by a fuzzy edge and a lump with an inflatable bronchus sign. The disease mainly relies on histopathology and immunohistochemical diagnosis. Surgical treatment combined with chemotherapy or chemotherapy alone has satisfactory results and is a malignant tumor with a relatively good prognosis.