多发性骨髓瘤（MM）是B淋巴细胞成熟阶段-浆细胞恶性肿瘤。典型MM诊断并不难，但早期常因临床表现缺乏特征、病型特殊、实验室条件不全或疏忽，易发生延迟诊断，甚至误诊。延迟诊断是指经门诊问诊、查体、X线与常规临床检验或入院7d仍未能确立诊断的病例。现结合我院自1965年1 Multiple myeloma (MM) is a maturation phase of B lymphocytes - a plasma cell malignancy. The diagnosis of typical MM is not difficult, but early often because of lack of clinical features, special type of disease, incomplete or negligent laboratory conditions, prone to delayed diagnosis, and even misdiagnosis. Delayed diagnosis refers to cases that have failed to establish a diagnosis after outpatient consultations, physical examinations, X-rays, and routine clinical tests, or 7 days after admission. Now combined with our hospital since 1965 1