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目的 :探讨血管性痴呆 (VD)病理机制并研究补肾醒脑方对血管性痴呆大鼠模型脑组织兴奋性氨基酸 (EAA)和抑制性氨基酸 (IAA)含量的影响。方法 :采用反复夹闭双侧颈总动脉伴低血压造成血管性痴呆大鼠模型 ,通过氨基酸自动分析仪检测脑组织谷氨酸 (Glu)、γ -氨基丁酸 (GABA)的含量。结果 :补肾醒脑高剂量组和补肾醒脑低剂量组均可以降低脑组织中Glu的含量 ,增加脑组织中GABA的含量。结论 :补肾醒脑方能抑制脑组织兴奋性氨基酸的释放 ,调节Glu/GABA系统平衡而减轻其兴奋性毒性 ,从而保护大脑神经细胞 ,这可能是补肾醒脑方治疗VD的作用机制之一。
Objective: To investigate the pathological mechanism of vascular dementia (VD) and study the effect of Bushen Xingnao Prescription on the contents of excitatory amino acids (EAA) and inhibitory amino acids (IAA) in brain tissue of vascular dementia rats. METHODS: The rat model of vascular dementia was established by repeatedly clipping bilateral common carotid arteries with hypotension. The contents of glutamic acid (Glu) and gamma-aminobutyric acid (GABA) in brain tissue were detected by amino acid automatic analyzer. Results: The high-dose Bushen Xingnao group and the Bushen Xingnao low-dose group can reduce the content of Glu in brain tissue and increase the content of GABA in brain tissue. Conclusion : Bushen Xingnao Prescription can inhibit the release of excitatory amino acids in brain tissue, regulate the balance of Glu/GABA and reduce its excitotoxicity, thus protecting brain neurons. This may be one of the mechanisms of Bushen Xingnao Prescription in the treatment of VD.