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目的评价国产头孢吡肟与进口头孢吡肟治疗呼吸道感染的临床疗效。方法检索CNKI数据库,收集1998年以来的国内公开发表的关于国产头孢吡肟与进口头孢吡肟治疗呼吸道感染的随机对照研究(RCT),对筛选出的文献用RevMan 4.2进行荟萃分析。结果共纳入5个RCT,两组的临床痊愈率、有效率和细菌清除率分别为62.70%、96.48%、95.77%和58.72%、90.64%、95.21%,综合OR值为1.20(95%CI为0.81～1.78,P=0.37)、2.75(95%CI为1.21～6.26,P=0.02)和1.14(95%CI为0.46～2.78,P=0.78),两组痊愈率和细菌清除率差异无统计学意义,有效率差异有统计学意义。结论国产头孢吡肟与进口头孢吡肟治疗呼吸道感染的临床疗效相似,甚至国产头孢吡肟的疗效要更好。
Objective To evaluate the clinical efficacy of domestic cefepime and imported cefepime in the treatment of respiratory tract infections. Methods The CNKI database was searched and collected. The randomized controlled study (RCT) of domestic published domestic and imported cefepime since 1998 was collected for the treatment of respiratory tract infection. The collected papers were analyzed by meta-analysis with RevMan 4.2. Results Five RCTs were included. The clinical cure rate, effective rate and bacterial clearance rate in the two groups were 62.70%, 96.48%, 95.77% and 58.72%, 90.64% and 95.21% respectively. The comprehensive OR was 1.20 (95% CI 0.81-1.78, P = 0.37), 2.75 (95% CI 1.21-6.26, P = 0.02) and 1.14 (95% CI 0.46-2.78, P = 0.78). There was no significant difference in cure rate and bacterial clearance between the two groups The significance of learning, the effective difference was statistically significant. Conclusion The domestic clinical efficacy of domestic and imported cefepime in the treatment of respiratory tract infection is similar, even the efficacy of domestic cefepime should be better.