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目的:探讨IL-17在大鼠肝移植急性排斥反应模型中的表达及作用。方法:选取32对健康状况相同的大鼠,随机分组后建立大鼠肝移植急性排斥反应动物模型。肝移植手术后取受体鼠的血浆标本和肝组织标本,对比两组受体大鼠的急性排斥反应,并测定两组大鼠的IL-17水平。结果:相较于异基因移植组受体大鼠而言,同基因移植组受体大鼠ALT和TBIL的平均含量更接近正常水平,急性排斥反应较弱。同时,同基因移植组受体大鼠术后IL-17水平明显高于异基因移植组,组间比较具有明显差异,P<0.05。结论:IL-17参与到大鼠肝移植急性排斥反应的发生过程,临床上可将IL-17水平作为急性排斥反应的衡量指标,以便及时发现移植受体的急性排斥反应,并及早作出有效应对。
Objective: To investigate the expression and role of IL-17 in rat model of acute rejection after liver transplantation. Methods: Thirty-two rats with the same health status were selected and randomly divided into groups to establish animal model of acute rejection after liver transplantation in rats. After liver transplantation, plasma samples and liver tissue samples of recipient mice were harvested. The acute rejection of the two groups of recipients was compared. The levels of IL-17 in the two groups were also determined. Results: Compared with allograft recipients, the mean levels of ALT and TBIL in the recipients of the same gene transplantation group were closer to the normal level, and the acute rejection was weaker. At the same time, the level of IL-17 in the same gene transplantation group was significantly higher than that in the allogeneic transplantation group, with significant difference between the two groups (P <0.05). CONCLUSION: IL-17 is involved in the process of acute rejection in rat liver transplantation. IL-17 level can be used as a measure of acute rejection in clinic in order to find the acute rejection of transplant recipients in time and make an effective response as soon as possible .