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目的 探讨乙型肝炎患者丁、戊、庚型肝炎病毒感染情况及其混合感染对发病的影响。方法 采用EIA法检测乙型肝炎患者血清中抗 -HDVIgM、抗 -HEVIgM和抗 -HGVIgG并比较与临床间关系。结果 各型乙肝患者中单纯HBV感染占6 9 .9% (10 0 /143) ,混合感染占 30 .1% (43/143) ;混合感染病例中 ,二重感染达 95 .3% (41/4 3) ,三重感染占 4.6 % (2 /4 3) ;丁、戊、庚肝抗体阳性率分别为 10 .5 % (15 /143)、11.9% (17/143)和 9.1% (13/143) ;各型乙肝患者丁、戊、庚肝病毒混合感染率由高到低依次为重型乙型肝炎 42 .5 % (17/4 0 )、急性乙型肝炎 36 .4% (12 /33)、慢性乙型肝炎 2 0 .8% (11/5 3)、乙肝肝硬化 17.6 % (3/17) ;混合感染病例ALT、SB较低。结论 乙型肝炎患者丁、戊、庚型肝炎病毒混合感染率较低 ,以二重感染常见 ;混合丁、戊、庚型肝炎病毒感染病例肝损轻、预后较好。
Objective To investigate the prevalence of hepatitis D, hepatitis E and hepatitis G virus infections and their mixed infection. Methods The serum levels of anti-HDVIgM, anti-HEVIgM and anti-HGVIgG in patients with hepatitis B were detected by EIA and compared with clinical data. Results HBV infection accounted for 69.9% (10 of 143 cases) and mixed infection of 30.1% (43/143) in all kinds of hepatitis B. In the mixed infection cases, the infection rate of double infection was 95.3% (41 / 4 3), and triple infection accounted for 4.6% (2/4 3) respectively. The positive rates of D, E and G were 10.5% (15/143), 11.9% (17/143) and 9.1% / 143). The mixed infection rates of hepatitis B, hepatitis E and hepadnavirus of all types of hepatitis B from high to low were as follows: 42.5% (17/40) of severe hepatitis B, 36.4% (12 / 33), 20.8% (11/5) of chronic hepatitis B and 17.6% (3/17) of hepatitis B cirrhosis. The ALT and SB of mixed infection were lower. Conclusions Hepatitis B, hepatitis E and Hepatitis G viruses have a low combined infection rate, which is common in double infection. Hepatitis B virus with mixed hepatitis E, G and G infections is mild with a good prognosis.