目的探讨急性白血病中 Pin1的表达及与 CyclinD1相关研究。方法用 S-P 免疫细胞化学染色方法检测62例初治急性白血病(AL),10例完全缓解期急性白血病(AL-CR)及15例正常对照组(骨髓像正常的非恶性血液病患者)骨髓单个核细胞中 Pin1、CyclinD1的表达。结果初治 AL 组的 Pin1表达阳性率为59.7%,AL-CR 组的表达阳性率为0%,正常对照组的表达阳性率为0%,初治 AL Objective To investigate the expression of Pin1 in acute leukemia and its relationship with CyclinD1. Methods Sixty-two patients with newly diagnosed acute leukemia (AL), 10 patients with complete remission acute leukemia (AL-CR) and 15 normal controls (patients with normal bone marrow non-hematologic malignancies) were examined by SP immunocytochemical staining. The expression of Pin1 and CyclinD1 in nuclear cells. Results The positive rate of Pin1 in primary AL group was 59.7%, the positive rate in AL-CR group was 0%, the positive control group was 0%