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内毒素(lipopolysaccharide/endotoxin,LPS)是革兰阴性菌胞壁外膜主要成分,由3部分组成:O-特异性侧链、核心多糖和脂质A(Lipid A)。LPS进入机体后,免疫细胞可通过相关模式识别分子识别LPS,诱发失控性炎症反应。其中,单核/吞噬细胞系统是LPS的主要效应细胞,其胞膜表面的模式识别受体是识别启动炎症反应的始动因素。肝脏是人体最大的清除外来有毒物质的器官,肝枯否细胞是全身最大的组织巨噬细胞群,是清除降解LPS的重要免疫细胞,肝窦状内皮细胞也可充当清道夫角色,可不依赖枯否细胞独立清除LPS[1]。本文就近
Lipopolysaccharide / endotoxin (LPS) is the main component of gram-negative cell wall adventitia and consists of 3 parts: O-specific side chain, core polysaccharide and Lipid A. After LPS enters the body, the immune cells recognize the LPS through cognate pattern recognition molecules and induce uncontrolled inflammatory responses. Among them, the mononuclear / phagocyte system is the main effector cells of LPS, and its pattern recognition receptors on the membrane surface are the initiators for identifying the inflammatory reaction. The liver is the body’s largest organ of removal of foreign toxic substances, hepatic cells is the body’s largest macrophage macrophages, is an important immune cells to degrade LPS, sinusoidal endothelial cells can also play the role of scavenger, can be independent of dry No cell independent clearance of LPS [1]. This article is near