细菌对 β-内酰胺类抗生素产生耐药性的最主要机理是产生了 β -内酰胺酶 ,为了有效地控制耐药菌的感染 ,开发酶抑制剂成了新药研制中的一个主要方向 .本文对β -内酰胺酶抑制剂的作用机制、特点、抗菌活性临床应用等方面进行了综述 The most important mechanism of bacterial resistance to β-lactam antibiotics is the production of β-lactamase, and in order to effectively control the infection of resistant bacteria, the development of enzyme inhibitors has become a major direction in the development of new drugs. The mechanism, characteristics and antibacterial activity of β - lactamase inhibitors were summarized