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本文通过慢性经口染毒试验,观察了醋酸铅对雄性小鼠的精子形态、精子数量、精子运动能力和雄性生育力的影响,及生殖器官的组织病理学改变。结果表明,饲以1%醋酸铅饲料3个月可出现精于畸形率增高,血铅明显升高;2%醋酸铅可使精子运动能力下降,精子计数减少,睾丸出现轻度损伤;4%醋酸铅可影响雄性生殖机能,平均活胎数减少,总死胎率升高。提示醋酸铅对雄性小鼠生殖细胞有潜在的诱变能力,并能使雄性生育力降低。
In this paper, chronic oral toxicity test observed the effect of lead acetate on male mice sperm morphology, sperm count, sperm motility and male fertility, and histopathological changes of genital organs. The results showed that feeding 1% lead acetate for 3 months could improve the rate of abnormal deformity and blood lead obviously; 2% lead acetate could decrease sperm motility, reduce sperm count and slight damage in testis; 4% lead acetate Affect male reproductive function, the average number of live births decreased, the total stillbirth rate increased. Tip lead acetate male mouse germ cells have potential mutagenic ability, and can reduce the male fertility.