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目的：为探讨肾综合征出血热病毒（ＨＦＲＳＶ）能否感染体外培养的人肾小球系膜细胞及在其中复制，能否引起细胞病变。方法：用ＨＦＲＳＶ７６－１１８株、ＳＲ－１１株和陈株分别攻击体外传代培养的人肾小球系膜细胞。结果：于培养第一代即在受染细胞的胞浆中检出特异性病毒抗原，阳性细胞数及胞浆内抗原的含量随传代次数的增加而增加．感染细胞在光镜下未见明显病理损害。结论：ＨＦＲＳＶ可以感染体外培养的人肾小球系膜细胞并可以在其中复制。
Objective: To investigate whether HFRSV can infect human glomerular mesangial cells cultured in vitro and replicate in vitro, and whether it can cause cytopathic effect. Methods: Human mesangial cells cultured in vitro were challenged with HFRSV76-118, SR-11 and Chen strains respectively. Results: In the first generation of infected cells that is detected in the cytoplasm of specific virus antigen, the positive cell number and cytoplasmic antigen content increased with the passage number increased. Infected cells in the light microscope showed no significant pathological damage. Conclusion: HFRSV can infect cultured human mesangial cells and replicate in it.