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目的:研究呼出气一氧化氮(FeNO)水平与支气管哮喘患儿病情及炎症因子的关系。方法:选择从2014年9月到2016年9月在我院接受治疗的支气管哮喘患儿115例作为观察组,另选同期来我院体检的健康儿童115例作为对照组,对比两组FeNO及炎症因子的水平,比较观察组不同病情患儿FeNO及炎症因子水平,分析患儿FeNO与病情及炎症因子的相关性。结果:观察组C反应蛋白(CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)以及FeNO水平分别为(5.06±1.29)mg/L、(4.32±1.33)pg/mL、(2.37±0.21)pg/mL、(50.82±18.28)ppb,均分别显著高于对照组的(1.33±0.46)mg/L、(1.52±0.48)pg/mL、(0.28±0.11)pg/mL、(18.23±2.46)ppb(均P<0.05)。观察组急性发作期患儿CRP、IL-6、TNF-α以及FeNO水平分别为(5.12±1.30)mg/L、(4.49±1.06)pg/mL、(2.48±0.19)pg/mL、(51.27±10.63)ppb,均分别显著高于缓解期的(2.97±0.82)mg/L、(2.39±0.62)pg/mL、(1.52±0.20)pg/mL、(32.41±5.52)ppb(均P<0.05)。根据Spearman法相关性分析可知,患儿FeNO与病情及IL-6、CRP、TNF-α均呈正相关(r=0.736、0.684、0.713、0.594;均P<0.05)。结论:支气管哮喘患儿的FeNO与炎症因子水平呈高表达,FeNO与病情及炎症因子之间密切相关,临床上可将其纳入监测指标,有助于辅助治疗支气管哮喘患儿。
Objective: To study the relationship between the level of exhaled nitric oxide (FeNO) and the condition and inflammatory factors in children with bronchial asthma. Methods: From September 2014 to September 2016, 115 children with bronchial asthma who were treated in our hospital were selected as the observation group. Another 115 healthy children who underwent physical examination in our hospital during the same period were selected as the control group. Inflammatory cytokines levels in children with different conditions were compared FeNO and inflammatory cytokines levels, analysis of children with FeNO and the disease and inflammatory factors. Results: The levels of CRP, IL-6, TNF-α and FeNO in the observation group were (5.06 ± 1.29) mg / L and (4.32 ± 1.33 ) were significantly higher than that of the control group (1.33 ± 0.46) mg / L, (1.52 ± 0.48) pg / mL, (2.28 ± 0.21) pg / 0.11) pg / mL, (18.23 ± 2.46) ppb (all P <0.05). The levels of CRP, IL-6, TNF-α and FeNO in the observation group were 5.12 ± 1.30 mg / L, 4.49 ± 1.06 pg / mL, 2.48 ± 0.19 pg / mL and 51.27 ± 10.63) ppb were significantly higher than those in the remission stage (2.97 ± 0.82 mg / L, (2.39 ± 0.62) pg / mL, (1.52 ± 0.20) pg / mL and (32.41 ± 5.52) 0.05). According to the Spearman correlation analysis, FeNO was positively correlated with the severity of illness, IL-6, CRP and TNF-α (r = 0.736,0.684,0.713,0.594; all P <0.05). CONCLUSION: FeNO and inflammatory cytokines in children with bronchial asthma are highly expressed. FeNO is closely related to the disease and inflammatory factors. It can be included in the monitoring indicators clinically, which is helpful to assist the treatment of children with bronchial asthma.