异基因造血干细胞移植后的患者,由于移植后免疫力尚未重建,同时长期使用免疫抑制剂预防移植物抗宿主病,致使其成为侵袭性真菌病的高发人群。鼻-眼眶-脑型毛霉菌病是一种罕见的侵袭性真菌病,由毛霉菌侵袭鼻窦黏膜及周边组织发展而来,病变可逐步侵蚀眼眶、上腭、颅神经、颅内大血管,造成组织坏死,导致患者失明、脑软化、死亡,预后极差。有关异基因造血干细胞移植术后的毛霉菌感染国内外鲜见报道,尤其是鼻-眼眶-脑型毛霉菌感染在国外多为 Patients after allogeneic hematopoietic stem cell transplantation have not been reconstructed because of the immunity after transplantation, meanwhile, immunosuppressive agents are used for a long time to prevent graft-versus-host disease, making them a high risk population of invasive mycosis. Nose - orbital - Mucous mycosis is a rare invasive fungal disease, caused by the invasion of mucocutaneous mucosa and surrounding tissues by Mucor, which can gradually erode the orbit, palate, cranial nerves, intracranial vessels, resulting in Tissue necrosis, leading to blindness, brain softening, death, poor prognosis. There are few reports of Mucormycosis after allogeneic hematopoietic stem cell transplantation in the world, especially in the nose-orbital-brain Mucormycosis in many foreign countries