论文部分内容阅读
测定了１０例健康志愿者及１０例硬皮病（ＰＳＳ）患者进餐前后胃肠道压力及血浆中胃肠激素的变化。结果显示，６６％ＰＳＳ有ＬＥＳ暂时性松弛，ＬＥＳ上１０ｃｍ处蠕动收缩振幅低、胃窦和十二指肠移行性运动复合波（ＭＭＣ）Ⅰ期所占时间长、ＭＭＣⅡ期收缩稀少、振幅低下或振幅不低但极其紊乱，其动力指数和消化期动力指数及ＭＭＣⅢ期收缩振幅均低于正常组。ＰＳＳ患者空腹血浆、ＶＩＰ，ＳＳＴ，ＮＴ和ＭＯＴ的累积增加面积均明显低于正常人。以上结果提示，ＰＳＳ患者胃肠道同时存在肌源性和神经源性病变，并表明其胃肠激素的释放可能有一定障碍。
The changes of gastrointestinal hormone and gastrointestinal hormones in 10 healthy volunteers and 10 patients with scleroderma (PSS) before and after meals were measured. The results showed that 66% of PSS had temporary relaxation of LES, low amplitude of peristaltic contraction at 10cm in LES, phase Ⅰ of gastric antrum and duodenal migratory motor complex (MMC), MMCⅡwere scarce and amplitude was low Or amplitude is not low but extremely disorder, the dynamic index and digestive motility index and MMC Ⅲ contraction amplitude were lower than the normal group. The cumulative area of increase in fasting plasma, VIP, SST, NT, and MOT in PSS patients was significantly lower than that in normal subjects. These results suggest that PSS patients with gastrointestinal tract both myogenic and neurogenic lesions, and that its release of gastrointestinal hormones may have some obstacles.