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糖尿病肾病（ＤＮ）是糖尿病的慢性并发症，是糖尿病患者的主要死亡原因之一，其发病机理未完全阐明，许多研究发现，ＤＮ的发病有家族聚集性，可能与遗传因素有关［１］。血管紧张素转换酶（ａｎｇｉｏｔｅｎｓｉｎ Ⅰ ｃｏｎｅｒｉｎｇ ｅｎｚｙｍｅ，ＡＣＥ）是肾素－血
Diabetic nephropathy (DN) is a chronic complication of diabetes mellitus. It is one of the major causes of death in diabetic patients. The pathogenesis of DN is not fully elucidated. Many studies have found that there is familial aggregation in the pathogenesis of DN, which may be related to genetic factors [1]. Angiotensin-converting enzyme (ACE) is renin-blood