目的:探讨Wernicke脑病(WE)的病因、临床表现特点、MRI表现及预后。方法:对10例WE患者的病因、临床表现、头颅MRI特点和预后进行了回顾性分析。结果:WE病因多与维生素B1缺乏有关,主要临床表现为眼肌麻痹,共济失调、精神异常三联症,但也可以表现为周围神经病、言语障碍等。头颅MRI有特异性部位的异常信号改变。及时予以维生素B1治疗者预后多良好。结论:提高临床对WE的认识,有利于早诊断、早干预,有助于改善WE的预后。 Objective: To investigate the etiology, clinical manifestations, MRI findings and prognosis of Wernicke’s encephalopathy (WE). Methods: The etiology, clinical manifestations, MRI features and prognosis of 10 cases of WE were retrospectively analyzed. Results: WE etiology and vitamin B1 deficiency, the main clinical manifestations of ophthalmoplegia, ataxia, mental disorders triad, but also can be manifested as peripheral neuropathy, speech disorders. Abnormal signal changes in specific parts of skull MRI. Vitamin B1 treatment in a timely manner the prognosis of the more good. Conclusion: To improve clinical awareness of WE is conducive to early diagnosis and early intervention, which can help to improve the prognosis of WE.