论文部分内容阅读
发作性睡病是一种常见的睡眠障碍。在美国人口中,估计其发病率约为0.09%。一般应用苯丙胺或哌醋甲酯之类的兴奋剂治疗有效,而三环抗抑郁剂有抗猝倒的作用。本文研究5例诊断为发作性睡病并有严重猝倒的成年男性患者,旨在观察其对丙咪嗪治疗反应的特征。患者年龄45—61岁(平均52.8岁),猝倒病程10—30年(平均25年);服哌醋甲酯和丙咪嗪至少一年,剂量分别为10—30mg/日(平均22.5mg/日,其中一例服药不规则)和125—200mg/日(平均163mg/日)。结果发现,患者猝倒发作频率由每日3—
Narcolepsy is a common sleep disorder. In the U.S. population, the estimated incidence is about 0.09%. The general application of amphetamine or methylphenidate agonists such as effective treatment, and tricyclic antidepressants have the role of anti cataplexy. In this study, 5 adult male patients diagnosed as narcolepsy with severe cataplexy were studied in order to investigate their response to imipramine treatment. Patients aged 45-61 years (mean 52.8 years), cats duration of 10-30 years (average 25 years); methylphenidate and imipramine at least one year, the dose was 10-30mg / day (average 22.5mg / Day, one case of irregular medication) and 125-200mg / day (average 163mg / day). The results showed that patients with cataplasm attack frequency by 3-