【摘 要】
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Dear Editor,Hair cells (HCs) clustered in cochlear sensory epithelia produce spontaneous spike and evoked action potentials during the developmental stage of au
【机 构】
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Laboratory of Neuropharmacology and Neurotoxicology, Shanghai University, Shanghai 200436, China
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Dear Editor,Hair cells (HCs) clustered in cochlear sensory epithelia produce spontaneous spike and evoked action potentials during the developmental stage of auditory,which rely on many ion channels,such as Ca2+ channels,K+ channels and Na+ channels (Housley et al.,2006;Marcotti et al.,2003).As the dominant molecule acting in action potentials in most of excitable cells,Na+ channels (VGSCs) were deemed to be indispensable in the spontaneous and evoked action potentials of HCs (Marcotti et al.,2003).The inward Na+ currents recorded from hair cells,shorten the time to reach the action-potential threshold (Eckrich et al.,2012).However,little was known about the tissue-or developmental expression and the molecular structural information of Na+channel subtype in hair cells,which extremely restricts the understanding of physiological mechanisms related to hearing development.
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