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目的:观察调经赞育丸对痛经的治疗作用及其机制。方法:催产素按20U/kg以及PGF2a按1.3mg/kg腹腔注射,制造小鼠痛经扭体模型。结果:与模型对照组比较,调经赞育丸能明显延长催产素所致小鼠痛经扭体潜伏时间(P<0.05或P<0.01),但对痛经扭体反应次数没有明显影响(P>0.05)。结论:调经赞育丸对痛经具有明显的治疗作用,可能与其降低子宫平滑肌对催产素和PGF2a等激素的敏感性有关。
Objective: To observe the therapeutic effect of Tiaojing Zayu Pills on dysmenorrhea and its mechanism. Methods: The oxytocin was injected intraperitoneally with 20 U / kg PGF2a and 1.3 mg / kg PGF2a to make the model of dysmenorrhea in mice. Results: Compared with the model control group, Tiaojing Zayu Pill could prolong the latent time of dysmenorrhea induced by oxytocin (P <0.05 or P <0.01), but had no significant effect on the number of writhing reaction (P> 0.05) ). Conclusion: Tiaojing Zayu Pill has significant therapeutic effect on dysmenorrhea, which may be related to the decrease of the sensitivity of uterine smooth muscle to hormones such as oxytocin and PGF2a.