缺氧诱导因子1是细胞在缺氧条件下产生的具有转录活性的核蛋白,由α亚单位和β亚单位构成,其中α亚单位被认为是特异性氧调节亚单位,决定了HIF1的活性。大量研究发现HIF1是肿瘤血管生成信号途径的关键性上游转录调控因子,通过影响其他血管生长因子的表达,而直接参与血管生成的全程。脑膜瘤是常见的颅内肿瘤,多呈实体性且血供丰富,在颅内呈膨胀性或侵袭性生长,其发生、发展与血管生成密切相关。深入研究HIF1在脑膜瘤中的表达及其对血管生成的调控可能为脑膜瘤的治疗发现新方法。 Hypoxia-inducible factor 1 is a transcriptionally active nucleoprotein that is produced by cells under hypoxia and consists of an alpha subunit and a beta subunit, wherein the alpha subunit is thought to be a specific oxygen regulatory subunit that determines the activity of HIF1 . Numerous studies have found that HIF1 is a key upstream transcriptional regulator of the tumor angiogenic signaling pathway and directly participates in the entire process of angiogenesis by affecting the expression of other vascular growth factors. Meningioma is a common intracranial tumor, mostly solid and abundant blood supply, in the intracranial swelling or invasive growth, its occurrence, development and angiogenesis are closely related. Further study on the expression of HIF1 in meningioma and its regulation of angiogenesis may be a new method for the treatment of meningioma.