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目的甲氨蝶呤联合米非司酮治疗输卵管妊娠的临床疗效。方法选取桑植县人民医院2013年7月—2016年7月收治的输卵管妊娠患者110例,随机分为对照组和观察组,各55例。对照组患者给予甲氨蝶呤治疗;观察组患者在对照组基础上给予米非司酮,两组患者均以5 d为1个治疗疗程。比较两组患者的临床疗效,治疗前及治疗1周后绒毛膜促性腺激素(β-h CG)浓度、盆腔包块直径,住院时间、住院费用、输卵管再通率及药物不良反应发生情况。结果观察组患者临床疗效优于对照组(P<0.05)。治疗前,两组患者血β-h CG浓度、盆腔包块大小比较,差异无统计学意义(P>0.05);治疗1周后,观察组患者血β-h CG浓度高于对照组,盆腔包块直径小于对照组(P<0.05)。观察组患者住院时间短于对照组,住院费用低于对照组,输卵管再通率高于对照组(P<0.05)。观察组患者不良反应发生率低于对照组(P<0.05)。结论甲氨蝶呤联合米非司酮治疗输卵管妊娠临床疗效确切,可有效提高β-h CG浓度,缩小盆腔包块直径,且住院时间短,住院费用低,还可有效提高输卵管再通率,降低不良反应发生率。
Objective To evaluate the clinical efficacy of methotrexate combined with mifepristone in the treatment of tubal pregnancy. Methods 110 patients with tubal pregnancy who were treated in Sangzhi People’s Hospital from July 2013 to July 2016 were randomly divided into control group and observation group, with 55 cases in each group. Patients in the control group were treated with methotrexate; patients in the observation group were given mifepristone on the basis of the control group, and both groups were given a course of treatment for 5 days. The clinical efficacy, the concentration of β-hCG, pelvic mass diameter, length of hospital stay, hospitalization cost, tubal recanalization rate and adverse drug reaction were compared between the two groups before treatment and after 1 week of treatment. Results The clinical efficacy of the observation group was better than that of the control group (P <0.05). Before treatment, there was no significant difference in β-h CG concentration and pelvic mass between the two groups (P> 0.05). After 1 week of treatment, the concentration of β-h CG in the observation group was higher than that in the control group, The diameter of the mass was smaller than that of the control group (P <0.05). The hospitalization time of observation group was shorter than that of control group, the hospitalization expense was lower than that of control group, and the tubal recanalization rate was higher than that of control group (P <0.05). The incidence of adverse reactions in observation group was lower than that in control group (P <0.05). Conclusion Methotrexate combined with mifepristone treatment of tubal pregnancy clinical curative effect is exact, which can effectively improve the concentration of β-h CG, reduce pelvic mass diameter, and shorter hospital stay, hospitalization costs, but also can effectively improve the tubal recanalization rate, Reduce the incidence of adverse reactions.