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目的探讨原发性肾上腺非霍奇金淋巴瘤的诊断与治疗。方法 2001年6月至2011年1月收治原发性肾上腺非霍奇金淋巴瘤2例,均为男性,平均年龄80岁。临床上均为查体发现,无特异性表现。肿瘤均位于左侧,直径平均5.7(5.5～6)cm。2例均行手术治疗,1例行腹腔镜左肾上腺肿瘤切除术,1例行开放性左肾上腺肿瘤切除术。结果病理诊断均为左肾上腺弥漫性大B细胞型淋巴瘤。术后均行美罗华(R-CHOP+环磷酰胺+阿霉素+长春新碱+泼尼松)方案治疗,1例已随访20个月,另1例随访6个月。结论原发性肾上腺非霍奇金淋巴瘤是一种罕见的恶性肿瘤,该病好发于老年男性,临床表现无特异性,明确诊断需依靠病理检查,该病恶性程度高,对治疗不敏感,预后差。
Objective To investigate the diagnosis and treatment of primary adrenal non-Hodgkin’s lymphoma. Methods Two cases of primary adrenal non-Hodgkin’s lymphoma were enrolled between June 2001 and January 2011. All were male and the average age was 80 years. Clinical examination is physical examination, no specific performance. The tumors were located on the left side and averaged 5.7 (5.5 to 6) cm in diameter. Two patients underwent surgical treatment. One patient underwent laparoscopic left adrenal tumor resection and one patient underwent open left adrenal tumor resection. Results The pathological diagnosis was left adrenal diffuse large B-cell lymphoma. All patients were treated with rituximab (R-CHOP + cyclophosphamide + doxorubicin + vincristine + prednisone) regimen. One patient had been followed up for 20 months and the other patient was followed up for 6 months. Conclusion Primary adrenal non-Hodgkin’s lymphoma is a rare malignant tumor. The disease occurs in elderly men and has no specific clinical manifestations. The definite diagnosis depends on pathological examination. The disease is highly malignant and insensitive to treatment. Poor prognosis.