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目的 为探讨庚型肝炎(hepatitis G,简称HG)的临床和病理特征。方法 用逆转录聚合酶链反应(RT-PCR)检测血清HGV-RNA;用HG单克隆抗体(monoclonal antibody,简称McAb)进行肝脏免疫组化,对临床和/或病理确诊的HGVRNA 阳性的急性或慢性庚型肝炎22例进行了系统的观察。结果HGV感染的血清学模式以与HBV、HCV、HAV、HEV重叠感染为主,占63.6％(14/22);单纯HGV感染者占36.4％(8/22)。HGV单纯感染者多呈隐匿性发病、症状轻、慢性化程度高。免疫组化显示:HGV在肝脏内分布仅呈现为胞浆型,感染细胞少。结论 HGV可引起急、慢性庚型肝炎。
Objective To investigate the clinical and pathological features of hepatitis G (HG). Methods Serum HGV-RNA was detected by reverse transcription-polymerase chain reaction (RT-PCR). Immunohistochemistry with monoclonal antibody (McAb) against HGV was performed to evaluate the clinical and / or pathological diagnosis of HGV RNA positive acute or Twenty-two cases of chronic hepatitis G were systematically observed. Results The serological patterns of HGV infection were mainly overlapping with HBV, HCV, HAV and HEV, accounting for 63.6% (14/22). HGV infection accounted for 36.4% (8/22). HGV infection was mostly occult onset, mild symptoms, high degree of chronicity. Immunohistochemistry showed that the distribution of HGV in the liver only showed cytoplasm, less infected cells. Conclusion HGV can cause acute and chronic hepatitis G.