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目的:建立黑地黄丸及其各单味药指纹图谱,探讨黑地黄丸复方水煎液与各单味药化学成分的异同。方法:水煎煮法制备黑地黄丸及其各单味药供试液,HPLC法建立其指纹图谱,对各色谱峰的归属进行分析,比对黑地黄丸复方水煎液与各单味药指纹图谱中药物化学成分的异同。结果:在黑地黄丸复方水煎液指纹图谱中共检出65个药源性成分,1个为煎煮后的化合产物。结论:黑地黄丸复方水煎液与各单味药指纹图谱中药物化学成分存在差异,复方经水煎煮后有新的化合产物生成。
OBJECTIVE: To establish the fingerprints of Hehuang Huang Wan and its single herbs, and to explore the similarities and differences between the chemical components of Heihuang Huang Wan decoction and the single herbs. Method: The decoction of the method of decoction of water and decoction of Heilonghuang Wan and its single herbs were respectively prepared. The fingerprints were established by HPLC. The ownership of each peak was analyzed. Similarities and Differences of Chemical Components in Fingerprints. Results: A total of 65 drug-derived components were detected in the fingerprints of the Heihuanghuang pill compound decoction. One was the compound product after decoction. Conclusion: There are differences in the chemical constituents in the fingerprints of the black decoction compound decoction and the single flavor decoction. The compound compound is produced after boiling in water.