论文部分内容阅读
目的:分析药品不良反应(ADR)发生特点及规律,为临床安全用药提供参考。方法:对2009~2015年我院收集的共6 382份ADR进行回顾性分析,分别按患者的年龄、性别、给药途径、药品种类、严重程度及ADR临床表现等进行分类统计。结果:6 382例ADR报告的男女患者比例为1∶1.07,41岁以上中老年患者所占比例最高(>60%)。一般的ADR报告数量最多,报告主体为医生(91.21%);静脉用药引发ADR有5 100例(79.91%),单一用药引发占88.55%;ADR主要导致消化系统损害(45.46%);ADR涉及22类药物,肿瘤药物居首位(1 677例,占26.28%);奥沙利铂(34.43%)、氨甲环酸(11.52%)和复方氨基酸(20AA)(9.65%)位列引起ADR的单品种前3位;严重不良反应共104例,以肿瘤药物(36.54%)和抗感染药(25.00%)为主。结论:临床工作中应重视ADR报告与监测,促进安全用药。
Objective: To analyze the characteristics and rules of adverse drug reaction (ADR) and provide reference for clinical safety medication. Methods: A total of 6 382 ADRs collected in our hospital from 2009 to 2015 were analyzed retrospectively. The patients’ age, sex, route of administration, drug type, severity and ADR clinical manifestations were respectively classified. RESULTS: The 6382 ADR cases reported a ratio of 1: 1.07 for both men and women, with the highest proportion (> 60%) of middle-aged and elderly patients over the age of 41 years. ADR was the most commonly reported doctor (91.21%); 5 100 cases (79.91%) of ADR were caused by intravenous drug use, 88.55% of them were induced by single drug; ADR mainly caused digestive system damage (45.46%); ADR involved 22 (1677 cases, accounting for 26.28%); ADR (34.43%), tranexamic acid (11.52%) and compound amino acids There were 104 cases of serious adverse reactions, which mainly consisted of tumor drugs (36.54%) and anti-infectives (25.00%). Conclusion: The clinical work should pay attention to ADR report and monitoring, to promote safe medication.