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1972年Texier等曾首先发现维生素K_1和其它药物一起作肌内注射后,引起这种硬皮病样皮下组织炎。当维生素K_1和另一种药物肌内注射几次之后,在臀部注射处出现红色斑块,单侧或双侧性。这种洋红色斑伴有刺痛感,片状扩展,二侧损害可于腰骶部融合。在停止用药后,红斑持续存在,于10～15天后,红斑减退。损害呈褐色,面积缩小,出现瘙痒感,皮下组织逐渐发生浸润,几个月后,形成旧象牙色的局限性硬皮病样状态,与深部组织粘连很紧。腰骶部和粗隆周围区脂肪最少的部位,损害最明显。 Texier的9个病例(男7女2)为肝硬化消化
In 1972, Texier et al. First found that vitamin K-1 and other drugs together for intramuscular injection, causing this scleroderma-like subcutaneous tissue inflammation. When vitamin K_1 and another drug were infused several times intramuscularly, red patches were found at the buttocks at the injection site, unilateral or bilateral. This magenta patch accompanied by tingling, flake expansion, bilateral damage may be in the lumbosacral fusion. After stopping the medication, erythema persists, after 10 to 15 days, erythema decreased. Damage is brown, area is reduced, there is a sense of pruritus, subcutaneous tissue gradually infiltration, a few months later, the formation of the old Ivory the limitations of scleroderma-like state, and deep tissue adhesion is very tight. Lumbosacral and trochanter around the least fat areas, the most obvious damage. Nine Texier cases (7 males and 2 females) were digested by cirrhosis