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纤溶酶原(PLG)经激活为纤溶酶(PLM)后,除了发挥纤溶和栓溶作用,还广泛参与胚胎发育、组织重构、伤口愈合等生理过程.近年来研究显示:PLM还与炎症、自身免疫、肿瘤和神经变性等存在紧密联系,而且已在细胞表面发现十几种PLG受体(PLGR)、结合蛋白.我们综述了这些受体和结合蛋白的结构、信号通路和致病机制方面的研究进展,从而为进一步理解纤溶系统的功能、发展新的诊疗方法提供思路.
Plasminogen activation (PLG), in addition to fibrinolytic and fibrinolytic activity, is also widely involved in physiological processes such as embryonic development, tissue remodeling, wound healing, etc. In recent years, studies have shown that PLM There is a close link between inflammation and autoimmunity, oncology and neurodegeneration, and more than a dozen PLG receptors (PLGRs), binding proteins, have been found on the cell surface. We review the structures, signaling pathways and mechanisms of these receptors and binding proteins Disease mechanism research progress, so as to further understand the function of fibrinolytic system, to provide new ideas for the development of diagnostic methods.