论文部分内容阅读
以氢氧化钠(NaOH)为催化剂、烯丙基溴(C3H5Br)为化学改性剂,合成了含双键的CD(环糊精)衍生物——6-O-烯丙基-β-CD。以反应时间、NaOH用量和C3H5Br用量为试验因素,以产率为考核指标,采用正交试验法优选出制备6-O-烯丙基-β-CD的最佳工艺条件。结果表明:当反应时间为48 h、n(β-CD)∶n(C3H5Br)=1∶66.4、n(NaOH)∶n(C3H5Br)=1.333∶1且反应温度为5～10℃时,产物的收率相对最大;红外光谱(FT-IR)、元素分析和核磁共振氢谱(1H-NMR)法表征结果表明,目标产物的预期结构被成功合成。
Using sodium hydroxide (NaOH) as catalyst and allyl bromide (C3H5Br) as chemical modifier, a 6-O-allyl-β-CD . The reaction conditions, the amount of NaOH and the amount of C3H5Br were used as experimental factors, and the yield was taken as the evaluation index. The optimum technological conditions for preparing 6-O-allyl-β-CD were optimized by orthogonal test. The results showed that when the reaction time was 48 h and the molar ratio of n (β-CD): n (C3H5Br) = 1:66.4 and n (NaOH): n (C3H5Br) = 1.333:1 and the reaction temperature was 5 ~ 10 ℃, (FT-IR), elemental analysis and 1H-NMR spectra showed that the expected structure of the target product was successfully synthesized.