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测定了 68例恶性淋巴瘤患者血清铜、锌、硒及铜 /锌比值水平 ,采用t检验和非条件Logistic回归因素分析方法对测定结果进行分析。结果表明 ,恶性淋巴瘤患者血清铜、铜 /锌比值升高 ,而血清锌及硒水平降低。血清铜和铜 /锌比值升高与肿瘤的负荷状态及病期明显有关。提示血清铜和铜 /锌比值的测定对监测恶性淋巴瘤患者的病情变化有一定价值。非条件Logistic多因素分析表明 ,血清锌、硒可能是恶性淋巴瘤发病的保护因素 ;而铜 /锌比值可能是危险指标。
Serum copper, zinc, selenium and copper/zinc ratios were measured in 68 patients with malignant lymphoma. The results were analyzed using t-test and non-conditional logistic regression analysis. The results showed that serum copper and copper/zinc ratios increased in patients with malignant lymphoma, while serum zinc and selenium levels decreased. The elevated serum copper and copper/zinc ratios are significantly related to the tumor’s load status and stage of disease. It is suggested that the determination of serum copper and copper/zinc ratio has some value in monitoring the change of the condition of malignant lymphoma patients. Non-conditional Logistic multivariate analysis showed that serum zinc and selenium may be protective factors for the onset of malignant lymphoma, and the copper/zinc ratio may be a risk indicator.