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唇腭裂患者术后的面中份发育不足等缺点与术后的瘢痕形成有关。而宫内唇腭裂手术修复的动物研究表明,其创口的愈合没有炎症和瘢痕形成。从而避免了出生后唇腭裂手术修复的一系列缺点。本文对宫内唇裂修复术的动物模型、手术方式、修复效果以及存在的问题等进行了简要的介绍。宫内修复术产生无瘢痕的效果,可能源于创口所处的特殊环境,以及创口的细胞外基质富含透明质酸所致。
Cleft lip and palate patient's face after the lack of medium and other shortcomings and postoperative scar formation. However, animal studies of intrauterine cleft lip and palate surgery have shown that there is no inflammation and scarring in the wound healing. Thus avoiding a series of shortcomings in the surgical repair of cleft lip and palate after birth. In this paper, intrauterine cleft lip repair animal models, surgical methods, the repair effect and the existing problems are briefly introduced. The effect of intrauterine repair without scarring may stem from the special environment in which the wound is located and the extracellular matrix of the wound is enriched with hyaluronic acid.